研究業績

最近の発表論文など

雑誌表紙

学術雑誌論文

2024

  • Z. Zheng, S. Grall, S. H. Kim, A. Chovin, N. Clement, and C. Demaille, “Activationless Electron Transfer of Redox-DNA in Electrochemical Nanogaps”, J. Am. Chem. Soc. 146, 9, 6094–6103 2024.
  • B. Scheidecker, S. Poulain, M. Sugimoto, T. Kido, T. Kawanishi, A. Miyajima, S. H. Kim, H. Arakawa, Y. Kato, M. Nishikawa, M. Danoy, Y. Sakai and E. Leclerc, “Dynamic, IPSC-derived hepatic tissue tri-culture system for the evaluation of liver physiology in vitro”, Biofabrication 16 025037, 2024.
  • B. Scheidecker, S. Poulain, M. Sugimoto, H. Arakawa, S. H. Kim, T. Kawanishi, Y. Kato, M. Danoy, M. Nishikawa, Y. Sakai, “Mechanobiological stimulation in organ-on-a-chip systems reduces hepatic drug metabolic capacity in favor of regenerative specialization”, Biotechnology and Bioengineering 1–18, https://doi.org/10.1002/bit.2865318, 2024.

2023

  • K. Hashimoto, T. Kumagai, K. Nomura, Y. Miyagawa, S. Tago, K. Takasaki, Y. Takahashi, H. Nishida, T. Ichinose, M. Hirano, H. Hiraike, O. Wada-Hiraike, Y. Sasajima, S. H. Kim and K. Nagasaka, “Validation of an on-chip p16ink4a/Ki-67 dual immunostaining cervical cytology system using microfluidic device technology”, Scientific Reports 13, 17052, 2023.
  • I. Madrid, Z. Zheng, C. Gerbelot, A. Fujiwara, S. Li, S. Grall, K. Nishiguchi, S. H. Kim, A. Chovin, C. Demaille, and N. Clement, “Ballistic Brownian Motion of Nanoconfined DNA”, ACS Nano 17, 17031-1740, 2023.
  • S. Li, Y. Coffinier, C. Lagadec, F. Cleri, K. Nishiguchi, A. Fujiwara, S. H. Kim, and N. Clément, “Single-Cell Electrochemical Aptasensor Array”, ACS Sens. 8, 2921–2926, 2023.
  • N. Lobato-Dauzier, R. Deteix, G. Gines, A. Baccouche, B. N. Hapsianto, S. Okumura, G. Mariette, D. Belharet, S. Queste, L. Jalabert, M. Denoual, Y. Rondelez, H. Toshiyoshi, H. Fujita, S. H. Kim, T. Fujii and A. J. Genot, “Silicon chambers for enhanced incubation and imaging of microfluidic droplets”, Lab on a Chip 23, 2854-2865, 2023.
  • M. Danoy, S. Poulain, R. Jellali, B. Scheidecker, Y. Tauran, L. Marjorie, B. Johanna, S. H. Kim, T. Kido, A. Miyajima, Y. Sakai, E. Leclerc, “Transcriptomic and proteomic studies suggest the establishment of advanced zonation-like profiles in hiPSCs-derived LSECs and CPM-positive LPCs cocultured in a fluidic microenvironment” Hepatology Research 53, 661–674, 2023.
  • Z. Zheng, S. H. Kim, A. Chovin, N. Clement, C. Demaille, “Electrochemical response of surface-attached redox DNA governed by low activation energy electron transfer kinetics”, Chemical Science 14 (13), 3652-3660, 2023.
  • K. Doi, H. Kimura, S. H. Kim, S. Kaneda, T. Wada, T. Tanaka, A. Shimizu, T. Sano, M. Chikamori, M. Shinohara, Y. T. Matsunaga, M. Nangakug and T. Fujii*, “Enhanced podocyte differentiation and changing drug toxicity sensitivity through pressure-controlled mechanical filtration stress on a glomerulus-on-a-chip”, Lab on a Chip 23, 437, 2023.
  • Simon Grall, Shuo Li, Laurent Jalabert, Soo Hyeon Kim, Arnaud Chovin, Christophe Demaille and Nicolas Clement, “Electrochemical Shot Noise of a Redox Monolayer”, Phys. Rev. Lett. 130, 218001, 2023.

2022

  • A. Essaouiba, R. Jellali, S. Poulain, F. Tokito, F. Gilard, B. Gakière, S. H. Kim, C. Legallais, Y. Sakai and E. Leclerc*, “Analysis of the transcriptome and metabolome of pancreatic spheroids derived from human induced pluripotent stem cells and matured in an organ-on-a-chip”, Mol. Omics, 18, 791-804, 2022.
  • K. Muto, I. Tsuchiya, S. H. Kim, S. Nagasawa, M. Takishita, K. Tsugawa, H. Saito, Y. Komazaki, T. Torii, T. Fujii, Y. Suzuki*, A. Suzuki, M. Seki, “Semibulk RNA-seq analysis as a convenient method for measuring gene expression statuses in a local cellular environment”, Scientific Reports 12, 15309, 2022.
  • S. Li*, Y. Coffinier, C. Lagadec, F. Cleri, K. Nishiguchi, A. Fujiwara, T. Fujii, S. H. Kim and N. Clement*, “Redox-labelled electrochemical aptasensors with nanosupported cancer cells”, Biosensors and Bioelectronics 216, 114643, 2022
  • J. Park, C. Park, Y. Sugitani, T. Fujii, and S. H. Kim*, “Electroactive microwell array device to realize simultaneous trapping of single cancer cells and clusters”, Lab on a Chip 22, 3000 - 3007, 2022.
  • A. Fauste-Gay, N. Lobato-Dauzier, A. Baccouche, Y. Rondelez, S. H. Kim, T. Fujii, N. Aubert-Kato and A. Genot, “Toggling between two limit cycles in a molecular ecosystem”, New Generation Computing 40, 703–721, 2022.
  • S. Grall, A. Kumar, L. Jalabert, S. H. Kim, G. Larrieu and N. Clement, “Random telegraph signals in nanoscale vertical junctionless transistors with gate-all-around”, Applied Physics Express 15, 075001, 2022.
  • B. N. Hapsianto , N. Kojima, R. Kurita, H. Yamagata, H. Fujita, T. Fujii, and S. H. Kim*, “Direct Capture and Amplification of Small Fragmented DNAs Using Nitrogen-Mustard-Coated Microbeads”, Analytical Chemistry, 94, 7594–7600, 2022.
  • M. Danoy, S. Poulain, B. Scheidecker, R. Jellali, Y. Tauran, M. Leduc, J. Bruce, F. Gilard, B. Gakiere, H. Arakawa, Y. Kato, S. H. Kim, T. Kido, A. Miyajima, Y. Sakai, E. Leclerc*, “Influence of CPM-dependent sorting on the multi-omics profile of hepatocyte-like cells matured in microscale biochips”, Biochemical Engineering Journal, 181, 108408, 2022.
  • M. H. Loo, Y. Nakagawa, S. H. Kim, A. Isozaki* and K. Goda*, “High-throughput sorting of nanoliter droplets enabled by a sequentially addressable dielectrophoretic array”, Electrophoresis, 43, 477–486, 2022.

2021

  • Y. Kutovyi, I Madrid, N. Boichuk, S. H. Kim, T. Fujii, L. Jalabert, A. Offenhaeusser, S. Vitusevich∗ and N. Clément∗, "Single-Trap Phenomena Stochastic Switching for Noise Suppression in Nanowire FET Biosensors", Jpn. J. Appl. Phys. 60, SBBG03, 2021.
  • S. Okumura, N. Benediktus, N. Lobato-Dauzier, Y. Ohno, S. Benner, Y. Torii, Y. Tanabe, K. Takada, A. Baccouche, M. Shinohara, S. H. Kim, T. Fujii, A. Genot∗, "Morphological manipulation of DNA gel microbeads with biomolecular stimuli", Nanomaterials 11(2), 293, 2021.

2020

  • Y. Kutovy, I. Madrid, I. Zadorozhnyi, N. Boichuk, S. H. Kim, T. Fujii, L. Jalabert, A. Offenhaeusser, S. Vitusevich∗ and N. Clément∗, "Noise suppression beyond the thermal limit with nanotransistor biosensors," Scientific Reports 10, 12678, 2020.
  • J. Park, T. Komori, T. Uda, K. Miyajima, T. Fujii, and S. H. Kim∗, "Sequential cell processing system by integrating hydrodynamic purification and dielectrophoretic trapping for analyses of suspended cancer cells," Micromachines 11, 47, 2020, featured as Cover of the issue.

2019

  • M. Takeuchi, K. Nagasaka, M. Yoshida, Y. Kawata, Y. Miyagawa, S. Tago, H. Hiraike, O. Wada-Hiraike, K. Oda, Y. Osuga, T. Fujii, T. Ayabe, S. H. Kim∗ and T. Fujii, "On-chip immunofluorescence analysis of single cervical cells using an electroactive microwell array with barrier for cervical screening," Biomicrofluidics 13, 044107, 2019, featured as Cover of the issue and selected as Editor's picks.
  • S. H. Kim∗, H. Ito, M. Kozuka, H. Takagi, M. Hirai and T. Fujii∗, "Cancer marker-free enrichment and direct mutation detection in rare cancer cells by combining multi-property isolation and microfluidic concentration," Lab on a Chip 19, 757, 2019, featured as Back Cover of the issue.

2018 and before

  • S. M. Nishikawa, S. H. Kim, Z. Luo, T. Kirihara, Y. Ikeuchi, T. Fujii and T. Levi∗, "Biomimetic microfluidic neurons for bio-hybrid experiments," Artificial Life and Robotics, Vol.23, pp.402-408, 2018.
  • S. H. Kim∗, H. Ito, M. Kozuka, M. Hirai and T. Fujii∗, "Localization of low-abundant cancer cells in a sharply expanded microfluidic step-channel using dielectrophoresis," Biomicrofluidics 11, 054114, 2017.
  • M. Antfolk∗, S. H. Kim, S. Koizumi, T. Fujii and T. Laurell∗, "Label-free single-cell separation and imaging of cancer cells using an integrated microfluidic system," Scientific Reports 7, 46507, 2017.
  • J.-W. Park, S. H. Kim, T. Ito, T. Fujii, S.Y. Kim, T. Laurell, S. W. Lee∗ and K. Goda∗, "Acoustofluidic harvesting of microalgae on a single chip," Biomicrofluidics 10, 034119, 2016.
  • S. H. Kim∗ and T. Fujii∗, "Efficient analysis of a small number of cancer cells at the single-cell level using electroactive double-well array," Lab Chip 16, 2440, 2016, featured as Front Cover of the issue.
  • Y.-J. Kim, S. H. Kim, T. Fujii and Y. T. Matsunaga∗, "Dual stimuli-responsive smart beads that allow "on-off" manipulation of cancer cells," Biomater. Sci. 4, 953-957, 2016.
  • S. H. Kim, M. Antfolk, M. Kobayashi, S. Kaneda, T. Laure∗ and T. Fujii∗, "Highly efficient single cell arraying by integrating acoustophoretic cell pre-concentration and dielectrophoretic cell trapping," Lab Chip 15, 4356, 2015.
  • M. Kobayashi, S. H. Kim, H. Nakamura, S. Kaneda and T. Fujii∗, "Cancer cell analyses at the single cell-level using electroactive microwell array device," PLoS ONE 10(11): e0139980, 2015.
  • H. Fujita, T. Esaki, T. Masujima, A. Hotta, S. H. Kim, H. Noji and T. M. Watanabe∗, "Comprehensive chemical secretory measurement of single cells trapped in a micro-droplet array with mass spectrometry," RSC Advances 5, 16968, 2015.
  • R. Watanabe∗, N. Soga, D. Fujita, K. V. Tabata, L. Yamauchi, S. H. Kim, D. Asanuma, M. Kamiya, Y. Urano, H. Suga∗ and H. Noji∗, "Arrayed lipid bilayer chambers allow single-molecule analysis of membrane transporter activity," Nature Communications 5, 4519, 2014.
  • S. H. Kim, X. He, S. Kaneda, J. Kawada, D. Fourmy, H. Noji and T. Fujii∗, "Quantifying genetically inserted fluorescent protein in single iPS cells to monitor Nanog expression using electroactive microchamber arrays," Lab Chip 14, 730, 2014.
  • H. Takehara, K. Miyazawa, T. Noda, K. Sasagawa, T. Tokuda, S. H. Kim, R. Iino, H. Noji and J. Ohta, "A CMOS image sensor with stacked photodiodes for lensless observation system of digital enzyme-linked immunosorbent assay," Jpn. J. Appl. Phys. 53, 04EL02, 2014.
  • S. H. Kim, S. Yoshizawa, S. Takeuchi, T. Fujii∗ and D. Fourmy∗, "Ultra-high density protein spots achieved by on chip digitalized protein synthesis," The Analyst 138, 4663, 2013.
  • S. H. Kim, S. Iwai, S. Araki, S. Sakakihara, R. Iino, and H. Noji∗, "Large-scale femtoliter droplet array for digital counting of single biomolecules," Lab Chip 12, pp. 4986-91, 2012.
  • R. Iino∗, K. Hayama, H. Amezawa, S. Sakakihara, S. H. Kim, Y. Matsumono, K. Nishino, A. Yamaguchi, and H. Noji, "A single-cell drug efflux assay in bacteria by using a directly accessible femtoliter droplet array," Lab Chip 12, pp. 3923-9, 2012.
  • K. Sasagawa∗, K. Ando, T. Kobayashi, T. Noda, T. Tokuda, S. H. Kim, R. Iino, H. Noji and J. Ohta, "Complementary Metal-Oxide-Semiconductor Image Sensor with Microchamber Array for Fluorescent Bead Counting," Jpn. J. Appl. Phys. 51, 02BL01, 2012.
  • S. H. Kim, T. Yamamoto, D. Fourmy∗, and T. Fujii∗, "Electroactive microwell arrays for highly efficient single-cell trapping and analysis," Small 7, pp. 3239-47, 2011.
  • S. H. Kim, T. Yamamoto, D. Fourmy∗, and T. Fujii∗, "An electroactive microwell array for trapping and lysing single-bacterial cells," Biomicrofluidics 5, p. 24114, 2011.
  • S. H. Kim, J. Y. Park, N. Park, J. H. Bae and J. Y. Yoo∗, "Direct numerical simulation of vortex synchronization due to small perturbations," J. Fluid Mech. 634, pp. 61-90, 2009.